Daftar Pembalap MotoGP 2025, Full Rider’s Line-up setelah Jack Miller resmi dikukuhkan menjadi rider Pramac Yamaha untuk musim depan. Francesco Bagnaia berpasangan dengan Marc Marquez di Ducati. Juara dunia MotoGP 2024, Jorge Martin, ada di tim Aprilia Racing bersama Marco Bezzechi.
Daftar Pembalap MotoGP 2025
| 2025 MotoGP rider line-up: | ||
| Rider | Team | Contract |
| Alex Marquez | Gresini Racing MotoGP | Gresini contract, end of 2026 |
| Maverick Vinales | Red Bull KTM Tech3 | ‘Multi-year contract’ |
| Enea Bastianini | Red Bull KTM Tech3 | ‘Multi-year contract’ |
| Marc Marquez | Ducati Lenovo Team | End of 2026 |
| Francesco Bagnaia | Ducati Lenovo Team | End of 2026 |
| Pedro Acosta | Red Bull KTM Factory Racing | ‘Multi-year contract’ |
| Brad Binder | Red Bull KTM Factory Racing | End of 2026 |
| Fabio Quartararo | Monster Energy Yamaha MotoGP | End of 2026 |
| Alex Rins | Monster Energy Yamaha MotoGP | End of 2026 |
| Jorge Martin | Aprilia Racing | ‘Multi-year contract’ |
| Marco Bezzecchi | Aprilia Racing | ‘Multi-year contract’ |
| Luca Marini | Repsol Honda Team | End of 2025 |
| Joan Mir | Repsol Honda Team | End of 2026 |
| Johann Zarco | LCR Honda Castrol | Honda contract, end of 2025 |
| Somkiat Chantra | LCR Honda Idemitsu | Honda contract, end of 2025 |
| Fermin Aldeguer | Gresini Racing MotoGP | Ducati contract, 2025 and 2026. Option for two further years. |
| Raul Fernandez | Trackhouse Racing | End of 2026 |
| Ai Ogura | Trackhouse Racing | End of 2026 |
| Miguel Oliveira | Prima Pramac Racing | Yamaha contract, 2025 and 2026 |
| Jack Miller | Prima Pramac Racing | Yamaha contract, 2025 |
| Fabio di Giannantonio | Pertamina Enduro VR46 | Ducati contract, 2025 and 2026 |
| Franco Morbidelli | Pertamina Enduro VR46 | End of 2025 |
| Riders leaving MotoGP at the end of 2024: | ||
| Rider | Team | Contract |
| Aleix Espargaro | Aprilia Racing | Retiring end of 2024, HRC test rider in 2025 |
| Augusto Fernandez | Red Bull Tech3 GASGAS | KTM contract end of 2024, Yamaha test rider in 2025? |
| Takaaki Nakagami | LCR Honda Idemitsu | Retiring end of 2024, HRC test rider in 2025 |
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